Evolutionary Systems Biology

We are interested in uncovering the principles of how mutations affect phenotypes at multiple levels of biological organization (gene expression, metabolic fluxes, etc.), and how these effects combine to determine organism’s fitness across environments. We approach this problem using experiments in model microorganisms S. cerevisiae and E.coli and mathematical modeling.

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Lab news

June 19, 2017

High-school student Joshua Chung joins the lab as an intern for the
summer.

June 19, 2017

Sergey submits internal proposal for the Pew Scholars Program. Super-cool
project on predicting evolution of antibiotic resistance! So, expecting
rejection.

June 16, 2017

Sergey finishes teaching his first undergraduate course, Population
Genetics. What a relief!

June 14, 2017

Sandeep finishes the sequencing library prep for his pilot experiment and submits it for sequencing. Fingers crossed!

June 8, 2017

Alena and Shohreh finish Phase I of the TnSeq experiment.
Sequencing library submitted. Fingers crossed!
propagation of mutational effects
News archive