Evolutionary Systems Biology

We are interested in uncovering the principles of how mutations affect phenotypes at multiple levels of biological organization (gene expression, metabolic fluxes, etc.), and how these effects combine to determine organism’s fitness across environments. We approach this problem using experiments in model microorganisms S. cerevisiae and E.coli and mathematical modeling.

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Lab news

March 29, 2017

Our paper with Elizabeth Jerison and others on genetic variation in
adaptability and pleiotropy in yeast is now on the bioRxiv.

March 14, 2017

Sean E. Guy joins the lab as a BS/MS student.

February 21, 2017

Sergey receives the Sloan Research Fellowship in Computational & Evolutionary Molecular Biology.

February 9, 2017

Sergey gives a talk at the San Diego Microbiology Group on the genetic variation in adaptability and pleiotropy – a work with Elizabeth Jerison and others that will soon appear on bioRxiv. Stay tuned!

February 2, 2017

Sandeep establishes a pipeline for full-genome sequence data analysis, largely based on previous work by Jeff Barrick and Ben Good.
propagation of mutational effects
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