Evolutionary Systems Biology

We are interested in uncovering the principles of how mutations affect phenotypes at multiple levels of biological organization (gene expression, metabolic fluxes, etc.), and how these effects combine to determine organism’s fitness across environments. We approach this problem using experiments in model microorganisms S. cerevisiae and E.coli and mathematical modeling.

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Lab news

August 17, 2017

Our paper with Elizabeth Jerison and others on genetic variation in adaptability and pleiotropy in yeast now published in eLife.

August 16, 2017

Sandeep’s preliminary analysis of his sequencing data inspires cautious optimism that his method might be working. Work continues.

August 11, 2017

ENLACE high-school students interns Lesly Delgado and Kevin Longoria give their final presentation at the ENLACE symposium and leave the lab. Good job!

August 1, 2017

New postdoc Justin Shaffer (PhD from U. Arizona) and new technician Krypton Carolino join our lab and the Meyer lab to work on gene drive evolution. Welcome!

July 26, 2017

Internal proposal for the Pew Scholars program rejected, of course. Not surprised – there are several exceptional junior faculty at UCSD very much worthy of the nomination – but was curious about the reason. Well, here it is: lack of creativity and independence. Wow. Respectfully disagree.
propagation of mutational effects
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